abstract：:Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls energy balance and its role in obesity remain unclear. Here, we show that brain-produced IL-6 is decreased in obese mice and rats in a neuroanatomically and sex...

journal_title：Cell reports

authors： Mishra D,Richard JE,Maric I,Porteiro B,Häring M,Kooijman S,Musovic S,Eerola K,López-Ferreras L,Peris E,Grycel K,Shevchouk OT,Micallef P,Olofsson CS,Wernstedt Asterholm I,Grill HJ,Nogueiras R,Skibicka KP

更新日期：2019-03-12 00:00:00

abstract：:Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often preclude resolving the granularity of neuron types. Combining gen...

journal_title：Cell reports

authors： Wang X,Tucciarone J,Jiang S,Yin F,Wang BS,Wang D,Jia Y,Jia X,Li Y,Yang T,Xu Z,Akram MA,Wang Y,Zeng S,Ascoli GA,Mitra P,Gong H,Luo Q,Huang ZJ

更新日期：2019-03-12 00:00:00

abstract：:Hepatocyte nuclear factor 4α (HNF4α) is a dimeric transcription factor that controls as much as 60% of all liver genes. However, how it achieves such broad functional diversity is unknown. Here, we show that inflammation and immune pathway genes are differentially regulated in an isoform-dependent manner, confirming t...

journal_title：Cell reports

authors： Ko HL,Zhuo Z,Ren EC

更新日期：2019-03-05 00:00:00

abstract：:Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surface expression on T cells fro...

journal_title：Cell reports

authors： Meryk A,Pangrazzi L,Hagen M,Hatzmann F,Jenewein B,Jakic B,Hermann-Kleiter N,Baier G,Jylhävä J,Hurme M,Trieb K,Grubeck-Loebenstein B

更新日期：2019-03-05 00:00:00

abstract：:Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons and their molecularly defined subsets in the...

journal_title：Cell reports

authors： Mehta P,Kreeger L,Wylie DC,Pattadkal JJ,Lusignan T,Davis MJ,Turi GF,Li WK,Whitmire MP,Chen Y,Kajs BL,Seidemann E,Priebe NJ,Losonczy A,Zemelman BV

更新日期：2019-03-05 00:00:00

abstract：:Activation of CaV2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated CaV2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that, under conditions of phy...

journal_title：Cell reports

authors： Weyrer C,Turecek J,Niday Z,Liu PW,Nanou E,Catterall WA,Bean BP,Regehr WG

更新日期：2019-02-26 00:00:00

abstract：:Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription d...

journal_title：Cell reports

authors： Scholes C,Biette KM,Harden TT,DePace AH

更新日期：2019-02-26 00:00:00

abstract：:Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA se...

journal_title：Cell reports

authors： Vigilante A,Laddach A,Moens N,Meleckyte R,Leha A,Ghahramani A,Culley OJ,Kathuria A,Hurling C,Vickers A,Wiseman E,Tewary M,Zandstra PW,HipSci Consortium.,Durbin R,Fraternali F,Stegle O,Birney E,Luscombe NM,Danovi D,

更新日期：2019-02-19 00:00:00

abstract：:Inability to mediate fed-fast transitions in the liver is known to cause metabolic dysfunctions and diseases. Intuitively, a failure to inhibit futile translation of state-specific transcripts during fed-fast cycles would abrogate dynamic physiological transitions. Here, we have discovered hepatic fed microRNAs that t...

journal_title：Cell reports

authors： Maniyadath B,Chattopadhyay T,Verma S,Kumari S,Kulkarni P,Banerjee K,Lazarus A,Kokane SS,Shetty T,Anamika K,Kolthur-Seetharam U

更新日期：2019-02-19 00:00:00

abstract：:Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides on the structured disk face of the nucleosome, is mediated by the Dot1L methyltransferase. Dot1L activity is part of a trans-histone crosstalk pathway...

journal_title：Cell reports

authors： Anderson CJ,Baird MR,Hsu A,Barbour EH,Koyama Y,Borgnia MJ,McGinty RK

更新日期：2019-02-12 00:00:00

abstract：:Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin rather than dopamine. These neurons normally release dopamine to inhibit pr...

journal_title：Cell reports

authors： Yip SH,Romanò N,Gustafson P,Hodson DJ,Williams EJ,Kokay IC,Martin AO,Mollard P,Grattan DR,Bunn SJ

更新日期：2019-02-12 00:00:00

abstract：:The yeast protein Ipa1 was recently discovered to interact with the Ysh1 endonuclease of the pre-mRNA cleavage and polyadenylation (C/P) machinery, and Ipa1 mutation impairs 3'end processing. We report that Ipa1 globally promotes proper transcription termination and poly(A) site selection, but with variable effects on...

journal_title：Cell reports

authors： Pearson EL,Graber JH,Lee SD,Naggert KS,Moore CL

更新日期：2019-02-12 00:00:00

abstract：:The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, th...

journal_title：Cell reports

authors： Urbain N,Fourcaud-Trocmé N,Laheux S,Salin PA,Gentet LJ

更新日期：2019-02-05 00:00:00

abstract：:Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains fail...

journal_title：Cell reports

authors： Salazar V,Jagger BW,Mongkolsapaya J,Burgomaster KE,Dejnirattisai W,Winkler ES,Fernandez E,Nelson CA,Fremont DH,Pierson TC,Crowe JE Jr,Screaton GR,Diamond MS

更新日期：2019-02-05 00:00:00

abstract：:The MEF2 family of transcription factors restricts excitatory synapse number in an activity-dependent fashion during development, yet MEF2 has not been implicated in long-term synaptic depression (LTD), which is thought to initiate synapse elimination. Mutations in MEF2 pathways are implicated in autism spectrum disor...

journal_title：Cell reports

authors： Andzelm MM,Vanness D,Greenberg ME,Linden DJ

更新日期：2019-01-29 00:00:00

abstract：:Pancreatic β cells secrete insulin by Ca2+-triggered exocytosis. However, there is no apparent secretory site similar to the neuronal active zones, and the cellular and molecular localization mechanism underlying polarized exocytosis remains elusive. Here, we report that ELKS, a vertebrate active zone protein, is used...

journal_title：Cell reports

authors： Ohara-Imaizumi M,Aoyagi K,Yamauchi H,Yoshida M,Mori MX,Hida Y,Tran HN,Ohkura M,Abe M,Akimoto Y,Nakamichi Y,Nishiwaki C,Kawakami H,Hara K,Sakimura K,Nagamatsu S,Mori Y,Nakai J,Kakei M,Ohtsuka T

更新日期：2019-01-29 00:00:00

abstract：:Katanin was the first microtubule (MT)-severing enzyme discovered, but how katanin executes MT severing remains poorly understood. Here, we report X-ray crystal structures of the apo and ATPγS-bound states of the catalytic AAA domain of human katanin p60 at 3.0 and 2.9 Å resolution, respectively. Comparison of the two...

journal_title：Cell reports

authors： Shin SC,Im SK,Jang EH,Jin KS,Hur EM,Kim EE

更新日期：2019-01-29 00:00:00

abstract：:Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the relative levels of proteins in diploid S. pombe cells during meiosi...

journal_title：Cell reports

authors： Krapp A,Hamelin R,Armand F,Chiappe D,Krapp L,Cano E,Moniatte M,Simanis V

更新日期：2019-01-22 00:00:00

abstract：:Wnts are a family of 19 extracellular ligands that regulate cell fate, proliferation, and migration during metazoan embryogenesis and throughout adulthood. Wnts are acylated post-translationally at a conserved serine and bind the extracellular cysteine-rich domain (CRD) of Frizzled (FZD) seven-pass transmembrane recep...

journal_title：Cell reports

authors： Speer KF,Sommer A,Tajer B,Mullins MC,Klein PS,Lemmon MA

更新日期：2019-01-22 00:00:00

abstract：:We provide a catalog for the effects of the human kinome on cell survival in response to DNA-damaging agents, covering all major DNA repair pathways. By treating 313 kinase-deficient cell lines with ten diverse DNA-damaging agents, including seven commonly used chemotherapeutics, we identified examples of vulnerabilit...

journal_title：Cell reports

authors： Owusu M,Bannauer P,Ferreira da Silva J,Mourikis TP,Jones A,Májek P,Caldera M,Wiedner M,Lardeau CH,Mueller AC,Menche J,Kubicek S,Ciccarelli FD,Loizou JI

更新日期：2019-01-15 00:00:00

abstract：:Most human cancers originate from high-turnover tissues, while low-proliferating tissues, like skeletal muscle, exhibit a lower incidence of tumor development. In Duchenne muscular dystrophy (DMD), which induces increased skeletal muscle regeneration, tumor incidence is increased. Rhabdomyosarcomas (RMSs), a rare and ...

journal_title：Cell reports

authors： Boscolo Sesillo F,Fox D,Sacco A

更新日期：2019-01-15 00:00:00

abstract：:EEG reverse-correlation techniques have revealed that visual information processing entails a ∼10-Hz (alpha) occipital response that reverberates sensory inputs up to 1 s. However, the spatial distribution of these perceptual echoes remains unknown: are they synchronized across the brain, or do they propagate like a t...

journal_title：Cell reports

authors： Lozano-Soldevilla D,VanRullen R

更新日期：2019-01-08 00:00:00

abstract：:The 26S proteasome is the central ATP-dependent protease in eukaryotes and is essential for organismal health. Proteasome assembly is mediated by several dedicated, evolutionarily conserved chaperone proteins. These chaperones associate transiently with assembly intermediates but are absent from mature proteasomes. Ch...

journal_title：Cell reports

authors： Nemec AA,Peterson AK,Warnock JL,Reed RG,Tomko RJ Jr

更新日期：2019-01-08 00:00:00

abstract：:Innate immunity is central to the pathophysiology of neurodegenerative disorders, but it remains unclear why immunity is altered in the disease state and whether changes in immunity are a cause or a consequence of neuronal dysfunction. Here, we identify a molecular pathway that links innate immunity to age-dependent l...

journal_title：Cell reports

authors： Shukla AK,Spurrier J,Kuzina I,Giniger E

更新日期：2019-01-02 00:00:00

abstract：:Intracellular transport and homeostasis of the endomembrane system in eukaryotic cells depend on the formation and fusion of vesicular carriers. Coat protein complex (COP) II vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER), whereas COPI vesicles facilitate traffic from the Golg...

journal_title：Cell reports

authors： Adolf F,Rhiel M,Hessling B,Gao Q,Hellwig A,Béthune J,Wieland FT

更新日期：2019-01-02 00:00:00

abstract：:RAS family GTPases contribute directly to the regulation of type I phosphoinositide 3-kinases (PI3Ks) via RAS-binding domains in the PI3K catalytic p110 subunits. Disruption of this domain of p110α impairs RAS-mutant-oncogene-driven tumor formation and maintenance. Here, we test the effect of blocking the interaction ...

journal_title：Cell reports

authors： Murillo MM,Rana S,Spencer-Dene B,Nye E,Stamp G,Downward J

更新日期：2018-12-26 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal death is still uncertain. Here, we used a Drosophila AD model expressing a secre...

journal_title：Cell reports

authors： Coelho DS,Schwartz S,Merino MM,Hauert B,Topfel B,Tieche C,Rhiner C,Moreno E

更新日期：2018-12-26 00:00:00

abstract：:Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in insulin secretion is largely unknown. Here, we show that a non-KATP K+ channel, KCNH6, plays a key role in insulin secretion and glucose hemostasis in humans and mice. KCNH6 p.P235L hetero...

journal_title：Cell reports

authors： Yang JK,Lu J,Yuan SS,Asan,Cao X,Qiu HY,Shi TT,Yang FY,Li Q,Liu CP,Wu Q,Wang YH,Huang HX,Kayoumu A,Feng JP,Xie RR,Zhu XR,Liu C,Yang GR,Zhang MR,Xie CL,Chen C,Zhang B,Liu G,Zhang XQ,Xu A

更新日期：2018-12-26 00:00:00

abstract：:Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the development of these pathological events. Rab4b expression is decreased in adipose T...

journal_title：Cell reports

authors： Gilleron J,Bouget G,Ivanov S,Meziat C,Ceppo F,Vergoni B,Djedaini M,Soprani A,Dumas K,Jacquel A,Yvan-Charvet L,Venteclef N,Tanti JF,Cormont M

更新日期：2018-12-18 00:00:00

abstract：:Calcium is a key regulator of mitochondrial function under both normal and pathological conditions. The mechanisms linking metabolic activity to mitochondrial Ca2+ signaling remain elusive, however. Here, by monitoring mitochondrial Ca2+ transients while manipulating mitochondrial membrane potential (ΔΨm), we found th...

journal_title：Cell reports

authors： Kostic M,Katoshevski T,Sekler I

更新日期：2018-12-18 00:00:00

abstract：:Fibrillarin (FBL) is a dual-function nucleolar protein that catalyzes 2'-O methylation of pre-rRNA and methylation of histone H2A at glutamine 104 (H2AQ104me). The mechanisms that regulate FBL activity are unexplored. Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deac...

journal_title：Cell reports

authors： Iyer-Bierhoff A,Krogh N,Tessarz P,Ruppert T,Nielsen H,Grummt I

更新日期：2018-12-11 00:00:00

abstract：:Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is used in an IT dosing regimen optimized for adaptive immunity to uncover requirem...

journal_title：Cell reports

authors： Sivick KE,Desbien AL,Glickman LH,Reiner GL,Corrales L,Surh NH,Hudson TE,Vu UT,Francica BJ,Banda T,Katibah GE,Kanne DB,Leong JJ,Metchette K,Bruml JR,Ndubaku CO,McKenna JM,Feng Y,Zheng L,Bender SL,Cho CY,Leong ML

更新日期：2018-12-11 00:00:00

abstract：:5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-l...

journal_title：Cell reports

authors： Cheng Y,Sun M,Chen L,Li Y,Lin L,Yao B,Li Z,Wang Z,Chen J,Miao Z,Xin N,Huang L,Allen EG,Wu H,Xu X,Jin P

更新日期：2018-12-11 00:00:00

abstract：:Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as phosphorylated ERK (pERK) in the establishment of memory engrams has been u...

journal_title：Cell reports

authors： Miyashita T,Kikuchi E,Horiuchi J,Saitoe M

更新日期：2018-12-04 00:00:00

abstract：:The achievement of the final form of an individual requires not only the control of cell size and differentiation but also integrative directional cues to instruct cell movements, positions, and orientations. In Drosophila, the adult epidermis of the abdomen is created de novo by histoblasts. As these expand and fuse,...

journal_title：Cell reports

authors： Mangione F,Martín-Blanco E

更新日期：2018-12-04 00:00:00

abstract：:Poverty, displacement, and parental stress represent potent sources of early life stress (ELS). Stress disproportionately affects females, who are at increased risk for stress-related pathologies associated with cognitive impairment. Mechanisms underlying stress-associated cognitive impairment and enhanced risk of fem...

journal_title：Cell reports

authors： Goodwill HL,Manzano-Nieves G,LaChance P,Teramoto S,Lin S,Lopez C,Stevenson RJ,Theyel BB,Moore CI,Connors BW,Bath KG

更新日期：2018-11-27 00:00:00

abstract：:The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1 and Esrp2 impairs e...

journal_title：Cell reports

authors： Lee S,Cieply B,Yang Y,Peart N,Glaser C,Chan P,Carstens RP

更新日期：2018-11-27 00:00:00

abstract：:Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injecte...

journal_title：Cell reports

authors： Kang Y,Ai Z,Duan K,Si C,Wang Y,Zheng Y,He J,Yin Y,Zhao S,Niu B,Zhu X,Liu L,Xiang L,Zhang L,Niu Y,Ji W,Li T

更新日期：2018-11-27 00:00:00

abstract：:Sensory processing can be tuned by a neuron's integration area, the types of inputs, and the proportion and number of connections with those inputs. Integration areas often vary topographically to sample space differentially across regions. Here, we highlight two visual circuits in which topographic changes in the pos...

journal_title：Cell reports

authors： Yu WQ,El-Danaf RN,Okawa H,Pacholec JM,Matti U,Schwarz K,Odermatt B,Dunn FA,Lagnado L,Schmitz F,Huberman AD,Wong ROL

更新日期：2018-11-20 00:00:00

abstract：:The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multiple structural models. Machine learning is used to analyze these models and pre...

journal_title：Cell reports

authors： Nimrod G,Fischman S,Austin M,Herman A,Keyes F,Leiderman O,Hargreaves D,Strajbl M,Breed J,Klompus S,Minton K,Spooner J,Buchanan A,Vaughan TJ,Ofran Y

更新日期：2018-11-20 00:00:00